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This anti-inflammatory response was mechanistically linked to the curcuminoids ability to inhibit the expression of toll-like receptors, toll-like receptor-2 (TLR-2) and TLR-4 at both the mRNA and protein levels, which are upstream regulators of NF-B and MAPK signaling pathways that drive cytokine production ( A synergistic approach combining natural products and targeted small molecules may offer a more effective strategy for addressing the multifactorial pathogenesis of NAFLD

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11 Our study results were similar to those of Zubair et al, 14 who reported that, similar to the results obtained for the placebo group, after 12 injections of glutathione over six weeks, only six (37.5%) participants experienced skin tone improvement of at least one level