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Epinephrine and AICAR-induced PGC-1 mRNA expression is intact in skeletal muscle from rats fed a high-fat diet

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Mi XS, Zhong JX, Chang RC, So KF

As OxS plays an important role in PSC activation and pancreatic fibrosis, we hypothesized that high glucose could stimulate pancreatic cells to produce excess ROS and activate PSCs, that induce pancreatic fibrosis and ultimately lead to -cell failure