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This is achieved through reduced CBS activity, which leads to downregulation of the trans-sulfuration pathway, and is accompanied by increases of BHMT and MTR, in order to enhance homocysteine remethylation capacity (Fig

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Based on these conflicted results, the association was speculated to be related to the clinical features of the population, stages of the disease, severity of copper excess, and types of detected specimens in these studies (Table 1)

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Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology

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