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CA treatment reduced OS and reactivated AKT/GSK3/FYN/Nrf2 signaling, significantly restoring HGHL-induced dysfunctions in MC3T3-E1 cells

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ROS, such as singlet oxygen ( 1 O 2 ), the superoxide radical (O), hydrogen peroxide (H 2 O 2 ) and the hydroxyl radical (OH ), are unavoidable by-products of aerobic metabolism (Foyer and Noctor, 2 O 2 as a component of the Foyer-Halliwell-Asada or ascorbate-glutathione pathway (Noctor and Foyer, 1998)

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( L ) Protein levels of FASN in primary hepatocytes following Chac1 overexpression using Adv

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These findings suggest that the interplay between ER stress and ferroptosis is complex and even contradictory

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