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Co-treatment with either BSO or EA led to intracellular Venetoclax accumulation in ABCC1-overexpressing HL-60 cells (Supplementary Fig

The histidine residue is essential for catalysis in HPII, and the side chain of valine residue makes the channel narrower to a diameter of about 3 that prevents any molecule larger than H 2 O and H 2 O 2 from gaining access to the active site

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Autophagy Autophagy is an intracellular catabolic process in which cell solutes and/or certain contents enter lysosomes for degradation under the regulation of the autophagy-related gene (ATG) protein family, thereby fulfilling the metabolic needs of cells and the renewal of a few organelles (Fig