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In particular, H 2 S, considered highly toxic, a poisonous gas with a typical odor of rotten eggs, is now classified among the endogenously produced gasotransmitters involved in many cell homeostatic processes as nitric oxide (NO) and carbon monoxide (CO), each other interacting [44,45]

Although we observed a reduction in total A, A 42 is the predominant isoform within plaques

Mutations in the HFE gene are the major cause of hereditary hemochromatosis, a genetic disorder characterized by impaired regulation of TfR-mediated iron uptake, leading to excessive iron absorption and iron overload in organs such as the liver, heart, pancreas, and joints, ultimately resulting in tissue damage (Brissot et al., 2018

Acknowledgements We thank Yale School Medicine, Yale West Campus, Systems Biology Institute and Cancer Biology Institute for the instrumentation supports