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79 Immune cells from people with fibromyalgia have demonstrated signs of mitochondrial dysfunction including low CoQ10 levels, increased oxidative stress, reduced mitochondrial capacity to generate energy, and increased removal of dysfunctional mitochondria

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Although our data indicate that myeloid-specific deficiency of Infgr1 resulted in improved insulin sensitivity by protecting adipose-resident macrophages from apoptosis, we cannot rule out the contributions of reduced food intake, increased activity, and reduced fat mass to the beneficial effects Future studies will be required to examine the significance of SerpinB2 expression by the macrophage subsets in infection clearance

M.UkhanovV.NagpalR.SalazarG