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Notably, in this study, vitamin D appears to influence the development of pulmonary fibrosis through multiple biological pathways: vitamin D deficiency not only exacerbates the lung inflammation caused by bleomycin (similar to the effect observed in the case of vitamin C deficiency), but also increases the likelihood of the occurrence of EMT in the lungs, and these are all crucial steps in the pathogenesis of pulmonary fibrosis

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Moreover, confocal microscopy revealed that GFP-ATG2A can form small punctate structures with ER-localized Cherry-ZDHHC11 within cells (Figs