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Circadian rhythms are driven and regulated through a transcriptional-translational feedback loop of core clock genes lasting approximately 24 h and are synchronized through exposure to the external light-dark cycle as a result of Earths daily rotation

Therefore, this review aims to synthesize the currently available in vitro models regarding ECD, emphasizing CVDs

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Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary Materials, further inquiries can be directed to the corresponding author