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128 Additionally, thalidomide inhibits M1 macrophage polarization by targeting the transcription factor IRF5, reduces the release of inflammatory signals, significantly reduces the secretion of the proinflammatory cytokines IL-12 and IFN-, and promotes intestinal mucosal healing

Research indicates that probiotic strains, by improving gut microbiota, can increase the expression of BDNF in the brain, thereby ameliorating depressive-like behavior (Zhang et al., 2023)

However, further studies on the precise localization and interaction of CoQH2-generating mitochondrial enzymes and LDHB are needed to determine their specific contribution to the anti-ferroptotic activity in mitochondria

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