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Role of the coagulation system in the pathogenesis of sickle cell disease

PollettaLVernucciECarnevaleIArcangeliTRotiliDPalmerioSet al

JCI Insight 2 (7), e90777

The results demonstrated that early and middle-stage treatment with hydrogen-saturated saline significantly improved cardiovascular and motor dysfunction, reduced neuronal loss, ROS, and -syn accumulation, and activated autophagy by inhibiting the PI3K/AKT/mTOR pathway