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By studying these effects, researchers aim to understand the molecular basis of anti-inflammatory processes at the cellular level

In the phase 1/2 trial, alpelisib (a PI3K inhibitor) plus nab-paclitaxel was well tolerated and showed encouraging efficacy, especially in patients with metastatic PIK3CA -mutated HER2 breast cancer, despite that TNBC has lower efficacy than HR+/HER2 patients

The targeted metabolomics data, including raw mass spectrometry files, have been deposited in the MetaboLights-compatible Metabolonote repository under accession number MPST000150

Dose ratios, injection timing, and complementary peptide layering are evaluated individually for each patient