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In summary, adding a small amount of copper to the subjects diets prevented this lethal anemia, suggesting that moderate amounts of zinc supplementation combined with small amounts of copper might help prevent neuron death in ALS

& Goh, K.-L

CBS, a heme protein, is active in the oxidized form, whereas methionine synthase is inactivated by oxidation and requires reductive methylation for reactivity (Chen and Banerjee, 1998