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Research has demonstrated higher 8-OHdG levels in CSF of non-demented PD patients than those in normal participants (Gmitterov et al., 2009)

It is possible to repeat these four steps to remove the preceding PLS predictors and add additional PLS predictors, but we choose to consider only one potential PLS predictor for the sake of keeping our model as simple and interpretable as possible and because this methodology is prone to overfitting when multiple PLS components are retained

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The core mediators of the immune system, the lymphocytes, perform their bacterial, viral and cancer cell killing function by generating large amounts of ROS, including superoxide and hydrogen peroxide