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CAT activity (EC 1.11.1.6) was determined by measuring the consumption of H 2 O 2 at 240 nm for 3 min at 25 C ( 240 = 39.4 mM 1 cm 1 ) (Aebi, 1984)

To this end, beta values of the calibration samples were computed with the R/bioconductor package Minfi 71 (v.1.24.0), genomic locations of the array probes were mapped from GRCh37 to GRCh38 using the UCSC liftOver command line tool 72 , and probes within 250 base windows were averaged