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There were two cases of dystonic reactions, two cases of fluid-responsive hypotension in patients with additional acute illness, three cases of asymptomatic bradycardia, one case of mild hypoxia requiring 2L of oxygen via nasal cannula, one patient that required non-invasive positive pressure ventilation in the setting of multifocal pneumonia, and one patient who had a seizure in the setting of concomitant benzodiazepine withdrawal

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Future intervention studies should use placebo-controlled designs with identical excipients to eliminate this bias

Therefore, 7,8-dimethoxycoumarin may be a viable option for potential melanin-producing activator and anti-grey hair applications