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Nature 621 , 373380 (2023)

As a result, defenses against ROS are activated 14 by an array of nonenzymatic antioxidants [metabolites such as ascorbate (AsA), carotenoids, glutathione (GSH) and proline] and antioxidant enzymes [such as guaiacol peroxidases (GPOX), catalase (CAT), superoxide dismutase (SOD) and AsA-GSH cycle enzymes like glutathione reductase (GR) ascorbate peroxidase (APX), monodehydroascorbate reductase (MDHAR), dehydroascorbate reductase (DHAR)], work together for detoxification of ROS 7,8,15,16,17,18,19,20

Under treatment strategies, delivering drug candidate within neural compartment is challenging and is dependent upon leucocytic transmission

Amiloride (Midamor) Amiloride can modestly reduce zinc excretion and increase zinc levels