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NIAAA Research Framework: Toward a Biological Definition of Alzheimer's Disease. Alzheimer's & Dementia 14: 535562

The use of growth factors, both in animal models and in clinical trials, has shown promising effects in protecting dopaminergic neurons and astrocytes in damaged regions by the activation of different signaling pathways important in neuronal survival and regeneration

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Challenges in therapeutic translation Targeting specificity & off-target toxicity A major challenge is achieving cardiomyocyte-specific ferroptosis modulation without harming other cells