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a 2021 peer-reviewed review states plainly that no NNMT-targeted clinical trials have been reported

This is because it binds to the same receptors as ghrelin (known as GHSR-1a receptors) and increases the amount of GH and IGF-1 thats secreted while reducing the amount of somatostatin, a GH-inhibiting hormone [3]

Conservative Frequency: Space initial treatments 6-8 weeks apart rather than standard 4-week intervals until skin tolerance confirms Women experiencing persistent postpartum skin sensitivity should consider extending the waiting period or selecting alternative treatments

Copper Peptide and Skin Regeneration Research