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Epub 2009 Jun 22

NAFLD could be considered an hepatic manifestation of metabolic syndrome, given the strong association with obesity, type 2 diabetes, hypertension and dyslipidaemia (3)

Failing cardiomyocytes have reduced Ca 2+ levels in the sarcoplasmic reticulum (SR)

However, it should be possible if needed by measurement of gamma-glutamylcysteine synthetase activity or mutational analysis (if the mutation in the family is known) of chorionic villi or cultured amniocytes