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Another study used fMRI to analyze whole-brain patterns of activation and also noted that viewing intensely happy faces generated an activity pattern that differentiated bipolar depression from MDD (148)

While severe inborn errors of folate metabolismsuch as those causing homocystinuriaare rare and typically result from deletions or deleterious mutations that abolish enzyme function, their dramatic clinical consequences have underscored the critical importance of this metabolic pathway [1-3]