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10.1093/oxfordjournals.molbev.a026406 51 MurataH.IharaY.NakamuraH.YodoiJ.SumikawaK.KondoT

Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells

Moreover, ferroptotic stress may not only contribute to tissue damage but also release proinflammatory mediators and damage-associated molecular patterns (DAMPs), reinforcing inflammation and accelerating tissue degeneration