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There are certainly exceptions to this rule, and one must always be aware that the action of a drug in the GI tract can also be profound such as with the antibiotics, producing diarrhea, constipation, and sometimes syndromes such as pseudo membranous colitis with the overgrowth of the bacteria C

A 3 g/day crystalline formulation for 4 weeks achieved clinical and endoscopic remission in 65% of patients [525], compared to 20% with placebo, while the low-dose 450 mg/day was ineffective [525]

We further examined the DNA binding site upstream of csiD by hydroxyl radical footprinting (Supplementary Figure 13a, b) 31

Komatsu K, Matsuura T, Ogawa T