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It's the first drug to show antipsychotic effects without blocking dopamine D2, which helps manage psychotic symptoms in Parkinson's without worsening its motor symptoms [104]

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For AIDs such as primary immune thrombocytopenia (ITP), sirolimus elicits suppressive immunomodulatory actions by augmenting the Treg cell proportion within the helper T lymphocyte subset, bolstering the count of naive T cells, triggering apoptosis in memory T cells, diminishing effector T cells, and enhancing megakaryocyte differentiation to expedite platelet production (228, 229)