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The essential role of nNOS-derived peroxynitrite on PARP activation in stroke has been attested by the significant prevention of PARP activation provided by genetic deletion (359) or pharmacological inhibition (1281) of nNOS

Hwang J-S, Kim K-H, Park J, Kim SM, Cho H, Lee Y, et al

Diagnosis can be challenging due to the broad range of symptoms, lack of traditional clinical presentation, and majority of knowledge based on small number of patients presented as case reports in the literature