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Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG et al (2003) The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

Despite these benefits, NPs show some toxicity to human tissues and cells depending on their various properties such as size [174], shape, functional surfaces [170] and concentration [175]

Although a few reports show increase in GSH levels in the sera of brain tumor patients [31], majority of studies concluded that brain tumors exhibit low GSH level [38, 46]

These modifications alter its conformation, preventing Keap1 from effectively binding to the ETGE and DLG motifs of NRF2