foxo4-dri senolytic peptide mechanism regulates endothelial cell senescence via the P53 signaling pathway FOXO4 - an overview |
FOXO4 an overview ScienceDirect Topics FOXO4 DRI Wikipedia Peptide Inhibitors Targeting FOXO4 p53 Interactions and Inducing Senescent Cancer Cell specific Apoptosis Journal of Medicinal Chemistry The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity.
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