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doi:10.3390/biomedicines12050573

Interestingly, when we compared our cryo-EM model to the isolated crystal structure of ENL (PDB: 6HQ0), we observed an inward movement of the loop containing ENL-Q41 (amino acids 37-42, backbone RMSD = 1.9), which is wedged into a groove formed by the CRBN N-lobe (Extended Data Fig