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Plasmid construction and yeast transformation All plasmids were constructed using conventional restriction enzyme-mediated cloning methods

110 Macrophage polarization refers to the process by which macrophages are stimulated by different signals in various microenvironments to change their phenotype and function

The deletion of the p53 gene alleviates the damage of HS to endothelial cells and inhibits the mitochondrial apoptosis pathway, which in turn proves that p53 translocation plays a crucial role in HS-mediated apoptosis [128]

doi: 10.1186/1471-2458-8-15 45 MoroRNBorisovASSaukkonenJKhanASterlingTRVillarinoMEet al