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Nat Commun 10 , 762 (2019)

Brown et al., 2003

The failure of mitragynine or 7-hydroxymitragynine to recruit -arrestin-2 may be an important factor separating the analgesic effect from the adverse effects of typical opiates such as abuse liability, respiratory depression and constipation

In accordance, the best seminogram regarding motility and the highest pregnancy rates during in vitro fertilization (IVF) were achieved with semen Se range of 6070 ng/mL, while the worst IVF success and all seminogram characteristics were associated with the semen Se 85% of the semen Se originates from the seminal plasma, and just a small proportion from the spermatozoa (88)