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Functional genomics approaches indicate that disruption of the functional cell-wall bound GGT1 isoform results in a constitutive alert response where anti-oxidative enzymes are up-regulated, probably as an effect of the altered plasma membrane receptors level and the redox state

P53 can inhibit cystine uptake by inhibiting the expression of SLC7A11, a vital component of the cystine/glutamate reverse transporter, thereby enhancing the sensitivity of cells to ferroptosis [32]

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Diagnosis A detailed review of recommendations suggesting preferred approaches to the diagnostic, therapeutic and preventive aspects of care has been described elsewhere ( Reference Chalasani, Younossi and Lavine 27 , Reference Ratziu, Bellentani and Cortez-Pinto 28 )