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The signaling pathways triggered by IL-4 and IL-13 recruit two distinct heterodimeric IL-4 receptors, type I IL-4R (comprising IL-4R and the c common cytokine receptor chains) and type II IL-4R (comprising IL-4R and IL-13R1 chains)

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Only in advanced PAH cases, X-ray may show indirect signs such as enlargement of the right ventricle or pulmonary artery, and protrusion of pulmonary vessels, therefore, X-ray has obvious shortcomings in the diagnosis of PAH