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J.DickersonB.et al (2022)

Without intervention, building muscle becomes nearly impossible regardless of how much you exercise

Similar to other GLP-1 drugs, CagriSema had mild to moderate side effects, which were mainly gastrointestinal (including nausea, vomiting, diarrhea, and constipation) and diminished over time

However, the high sequence identity (53%) and the same active site shared between human fumarase and Mtb fumarase pose a challenge in developing anti-tuberculosis drugs targeting this enzyme [287]