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Methods Amplified chemiluminescence was used to measure reactive oxygen species production by colonic biopsy specimens from rats with acetic acid induced colitis and to assess the in vitro effect of conventional antioxidants, standard therapies and proposed novel therapies for inflammatory bowel disease

Studies have shown that mitochondrial dysfunction is strongly associated with ferroptosis, a hallmark of diabetes-related complications (He et al., 2022)

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Together, these studies highlight the essential roles that SLC39A8 plays in intestinal Mn absorption and epithelial integrity and suggest a possible therapeutic target for inflammatory bowel disease (IBD) associated with impaired Mn homeostasis