foxo4-dri peptide senolytic animal model 2023 Frontiers The FOXO4 peptide in a
The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity. FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway PMC FOXO4 DRI Averix Labs The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications
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