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SOD1 is an enzyme that catalyzes the dismutation of superoxide radicals into hydrogen peroxide and oxygen, providing a crucial antioxidant defense

Conclusions PD remains a challenging neurodegenerative disease due to its complex pathology and limitations in existing therapies

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In this process, SQOR directly transfers electrons from H 2 S oxidation to the coenzyme Q (CoQ) pool in the electron transport chain, tightly coupling H 2 S removal with cellular energy production and redox homeostasis ( 2 S-mediated inhibition of complex IV, as illustrated by the severe metabolic crises seen in SQOR deficiency ( 2 S (preventing its accumulation in mitochondria), but also plays a central regulatory role in maintaining cellular energy balance and managing oxidative stress, serving as a key junction between sulfur metabolism and bioenergetics (Figure 1 illustrates the H 2 S metabolic pathway