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10.3390/jcm8010090 16 ChenZ.ChenH.YuL.XinH.KongJ.BaiY.et al (2021a)

Although synthetic agonists of PRRs, such as TLR and STING agonists, have shown strong potential, their effective delivery into poorly perfused or fibrotic tumors remains challenging, and systemic administration carries a risk of off-target inflammation