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For the acquired DOX-resistant PC3 prostate cancer cell line, QUE was found to reverse its resistance by inhibiting c-Met and PI3K/AKT signaling pathways (53)

Two periods of 90 days of trimetazidine (60 mg/day) also increased cardiac phosphocreatine/ATP ratio in nine patients (but three patients showed a decrease), which indicated improved mitochondrial energetics [146]

Perles L, Titt U, Mirkovic D, Mohan R

HIF-1 activation not only regulates the expression of glycolysis-related enzymes, such as hexokinase and lactate dehydrogenase but also enhances the expression of glucose transporters (GLUT), thereby increasing glucose uptake by tumor cells (51)