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By the Bayesian framework, the estimated prevalence of PCD was 1:17,576 (95% confidence interval: 1:22,5511:14,001)

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L-carnitine doses range from 1 to 3 grams daily, often split into two doses

step 1 The product of step 1 (41.0 g) and KOH (32.0 g) was dissolved in 200 ml of methanol, added 35.5 ml bromoethane, heated under reflux for 2 h, added 200 ml of 5% NaOH after cooled, and reacted for 3 4 h, added 600 ml ice water after reaction, stirred, rested and filtered, washed with water, recrystallised with 500 ml ethanol and dried at 80 C