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The immune response to this damage, characterized by M1 macrophage polarization, neutrophilic inflammation, and Th17 activation, further exacerbates lipid peroxidation and ferroptosis, creating a vicious cycle that drives disease progression

This may be especially of concern for older adults and those with sarcopenia (accelerated muscle loss)

Charoenwongpaiboon T, Punnatin P, Klaewkla M, Pramoj Na Ayutthaya P, Wangpaiboon K, Chunsrivirot S, Field RA, Pichyangkura R (2020) Conserved calcium-binding residues at the Ca-I site involved in fructooligosaccharide synthesis by Lactobacillus reuteri 121 inulosucrase