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Both stimulate growth hormone, but the way they work and the timeline for results differ in important ways

doi: 10.1074/jbc.M109.001099 183 SamuniY.CookJ

By disrupting the interaction between FOXO4 and p53, FOXO4-DRI allows the natural cell death pathway to proceed in damaged or senescent cells

While it might seem counterintuitive to stimulate the glucagon receptor (as glucagon raises blood sugar), in this context, it has a profound effect on energy expenditure