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The disruption of the HGF/c-MET signaling pathway, which has been preserved through evolution, leads to a complex array of events within cells that contribute to the development of tumors
The downstream effects include activation of hormone-sensitive lipase in adipose tissue (which breaks down stored triglycerides into free fatty acids), increased protein synthesis in skeletal muscle, enhanced cellular repair and turnover, elevated IGF-1 production from the liver, and improved lipid metabolism including reduced triglycerides
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