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Overcoming these barriers requires multidisciplinary collaboration: leveraging medicinal chemistry to optimize drug-like properties, utilizing toxicology to define safety margins, and applying systems biology to guide the design of precision clinical trials

doi: 10.1016/j.xcrm.2023.101254 80 ShahbazSBozorgmehrNLuJOsmanMSliglWTyrrellDLet al

This can trigger: salt precipitation peptide aggregation or a combination of both When the Solvent and the Vial Dont Match A lyophilised vial is not just peptide

As a consequence, the fragmentation does not have to happen on the weakest bond within the compound as would be the case with CID or IRMPD techniques