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For instance, patients with chronic intestinal inflammatory diseases, such as inflammatory bowel disease (IBD), often exhibit impaired intestinal barrier function and increased mucosal permeability, which facilitates bacterial translocation (137)

Aside from their role in modulation of the innate immune response, we also found that HOCl-modified plasma proteins act as highly effective holdase-like chaperones, protecting other proteins from HOCl-induced aggregation [37] (Fig

The pan-PPAR agonist lanifibranor decreased hepatic lipid accumulation, liver enzyme levels, and biomarkers of inflammation in plasma and improved fibrosis in an IIb clinical trial

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