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As mentioned earlier, the most important effect of incretins is to stimulate the production and secretion of insulin by the pancreas, and clinical studies show that the activation of this process, whether by stimulation of GLP-1 by semaglutide alone or simultaneous stimulation of GLP-1/GIP by tirzepatide, is associated with better glycemic control in type 2 diabetics

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Perhaps the FDAs pilot PRIME initiative on a pathway to approving excipients independent of associated bioactive molecules will provide new options for enhancer selection