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While NMN increased oxygen consumption and endurance, it is important to note that NMN did not affect the activity of mitochondrial Oxphos complexes or key enzymes of the TCA cycle 256

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This represents a fundamental safety distinction from full-length human growth hormone, which consistently elevates IGF-1 through traditional growth hormone receptor activation

This structural selectivity means AOD-9604 cannot trigger the intracellular signaling cascades normally initiated by growth hormone receptor activation