mitochondrial glutathione depletion
mitochondrial glutathione depletion injury and in HepG2 cells treated π§ͺ Glutathione Depletion Pathways 1.
Glutathione Depletion Pathways 1. Precursor Depletion Key bottleneck: Cysteine availability. Source: Diet or hepatic transsulfuration (methionine homocysteine cysteine). Failure mode: Downregulation of cystathionine lyase (CSE) during Controlling glutathione entry into mitochondria: potential roles for SLC25A39 in health and (treatment of) disease Signal Transduction and Targeted Therapy Maturation of Cytosolic Iron Sulfur Proteins Requires Glutathione* Journal of Biological Chemistry Mitochondrial Probe for Glutathione Depletion Reveals NME3 Essentiality for Mitochondrial Redox Response ACS Chemical Biology
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