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Conclusions We should bear in mind that while supplemental oxygen can lead to a marginal increase in systemic oxygen delivery (although the degree of efficacy depends on the type of hypoxia), it may also induce serious adverse effects on inflammation, oxidative stress, the pulmonary function, microvascular perfusion, and the coronary and cerebral blood flow

For example, researchers may perform preliminary analysis with minimal effort and the results may influence their decision to continue

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Low B12 is common in vegetarians, the elderly and those with conditions affecting nutritional absorption