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On the other hand, inactivation of CDKN2A gene encoding the tumor suppressor p16INK4a might facilitate escape from senescence in these cells, explaining the association between p16INK4a loss and worse outcomes in PA patients ( Table 2 List of in vitro models developed for preclinical testing

Among the recent technologies in treating Parkinsons disease is nanotechnology, which has been used with the aim of delivering molecular drugs in small quantities in the brain to reduce the side effects of various drugs and medications [171]

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