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Natural history of GATA1 mutations in Down syndrome

Increased frequency of cluster of differentiation 14 (CD14+) monocytes expressing interleukin 1 beta (IL-1) in Alzheimers disease patients and intermediate levels in late-onset depression patients

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-ketoglutarate in the TCA cycle is the precursor of glutamine, and impaired TCA cycle function and astrocyte glutamine transfer influence the supply of glutamine for glutamate and GABA synthesis, leading to functional disruption in the brain (Zhou Y